Which secretes bile

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Your subscribed friend will also get 1 month subscription absolutely free. Ask Your Doubts We are really eager to clarify your doubts. Join Now. Company About Us. Our Team. Our Faculty. Behind the Scene. Tutorix for Schools. Contact Us. Prokaryotic Cell - One chromosome II. Eukaryotic Cells - More than one chromosome. Which organism causes rust of wheat?

In which part of the human body is the pituitary gland located? Suggested Test Series. Suggested Exams. More General Science Questions Q1. Isotopes - different mass number II. Isobars - same mass number. Which of the following is true? Hepatic synthesis of bile acids accounts for the majority of cholesterol breakdown in the body. In humans, roughly mg of cholesterol are converted to bile acids and eliminated in bile every day. This route for elimination of excess cholesterol is probably important in all animals, but particularly in situations of massive cholesterol ingestion.

Interestingly, it has recently been demonstrated that bile acids participate in cholesterol metabolism by functioning as hormones that alter the transcription of the rate-limiting enzyme in cholesterol biosynthesis. Large amounts of bile acids are secreted into the intestine every day, but only relatively small quantities are lost from the body.

Venous blood from the ileum goes straight into the portal vein, and hence through the sinusoids of the liver. Hepatocytes extract bile acids very efficiently from sinusoidal blood, and little escapes the healthy liver into systemic circulation.

Bile acids are then transported across the hepatocytes to be resecreted into canaliculi. The net effect of this enterohepatic recirculation is that each bile salt molecule is reused about 20 times, often two or three times during a single digestive phase. It should be noted that liver disease can dramatically alter this pattern of recirculation - for instance, sick hepatocytes have decreased ability to extract bile acids from portal blood and damage to the canalicular system can result in escape of bile acids into the systemic circulation.

Assay of systemic levels of bile acids is used clinically as a sensitive indicator of hepatic disease.